Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873798 | 0.89 | PDE4A (0.40) | — | |
| SCHEMBL873648 | 0.88 | DPP4 (0.39) | HTR6ADRA1DADRA1AADRA1BSLC6A2 | |
| SCHEMBL874143 | 0.84 | DPP4 (0.40) | ADRA1DADRA1AADRA1BHCRTR1PTGDR | |
| SCHEMBL683346 | 0.80 | NR1H2 (0.41) | HTR6HCRTR1PTGDRCCR5MEN1 | |
| SCHEMBL2139694 | 0.80 | NR1H2 (0.41) | HTR6HCRTR1PTGDRCCR5MEN1 | |
| SCHEMBL683396 | 0.75 | NR1H2 (0.46) | ADRA1DADRA1AADRA1BHCRTR1PTGDR | |
| SCHEMBL2139740 | 0.75 | NR1H2 (0.46) | ADRA1DADRA1AADRA1BHCRTR1PTGDR | |
| SCHEMBL876415 | 0.74 | PDE4A (0.40) | — | |
| SCHEMBL683311 | 0.74 | HCRTR1 (0.45) | ADRA1DADRA1AADRA1BHCRTR1PTGDR | |
| SCHEMBL874137 | 0.74 | HCRTR1 (0.45) | ADRA1DADRA1AADRA1BHCRTR1PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643000-A2 | THERAPEUTIC PIPERAZINES | Dart Neuroscience (Cayman) Ltd (KY) | 2013-10-02 | — | — | EP | claimed |
| WO-2012040258-A2 | THERAPEUTIC PIPERAZINES | HELICON THERAPEUTICS, INC. (US) | 2012-03-29 | — | — | WO | claimed |