Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.41 |
| ▸ | PDE4A | P27815 | 11/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL877011 | 0.87 | PDE4A (0.39) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL877012 | 0.87 | PDE4A (0.39) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL876415 | 0.86 | PDE4A (0.40) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL874491 | 0.86 | PDE4A (0.46) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL873798 | 0.84 | PDE4A (0.40) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL873439 | 0.83 | PDE4A (0.45) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL874226 | 0.83 | PDE4A (0.47) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL873397 | 0.83 | PDE4A (0.42) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL873453 | 0.83 | PDE4A (0.42) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL873372 | 0.82 | PDE4A (0.41) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643000-A2 | THERAPEUTIC PIPERAZINES | Dart Neuroscience (Cayman) Ltd (KY) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012040258-A2 | THERAPEUTIC PIPERAZINES | HELICON THERAPEUTICS, INC. (US) | 2012-03-29 | — | — | WO | disclosed |