Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.64 |
| ▸ | GSK3B | P49841 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.60 |
| ▸ | FEN1 | P39748 | 1/20 | 0.60 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1533600 | 0.98 | SMN1; SMN2 (0.62) | SMN1; SMN2MAPTL3MBTL1PTPN1GSK3B | |
| Bromide SCHEMBL1443516 | 0.98 | SMN1; SMN2 (0.62) | SMN1; SMN2MAPTL3MBTL1PTPN1GSK3B | |
| SCHEMBL883159 | 0.91 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPTL3MBTL1PTPN1GSK3B | |
| Hydrochloric Acid SCHEMBL690938 | 0.89 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPTL3MBTL1PTPN1GSK3B | |
| SCHEMBL10337516 | 0.86 | MAPT (0.64) | SMN1; SMN2MAPTL3MBTL1PTPN1GSK3B | |
| SCHEMBL45515 | 0.86 | MAPT (0.64) | SMN1; SMN2MAPTL3MBTL1PTPN1GSK3B | |
| SCHEMBL9683457 | 0.85 | MAPK13 (0.55) | SMN1; SMN2MAPTL3MBTL1PTPN1GSK3B | |
| Hydrochloric Acid SCHEMBL194804 | 0.84 | MAPT (0.61) | SMN1; SMN2MAPTL3MBTL1PTPN1GSK3B | |
| Water SCHEMBL18694848 | 0.84 | MAPT (0.61) | SMN1; SMN2MAPTL3MBTL1PTPN1GSK3B | |
| Bromide SCHEMBL19378722 | 0.84 | MAPT (0.61) | SMN1; SMN2MAPTL3MBTL1PTPN1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611003-B1 | Substituted phenyl sulfonamides as selective B3 agonists for the treatment of diabetes and obesity | MERCK & CO INC (US) | 1997-06-18 | — | — | EP | claimed |
| EP-0379145-B1 | Substituted quinolinecarboxylic acids | AMERICAN CYANAMID CO (US) | 1997-05-07 | — | — | EP | disclosed |
| EP-0653421-B1 | Process for preparing 2-cyanoimidazole compounds | ISHIHARA SANGYO KAISHA (JP) | 1997-01-15 | — | — | EP | disclosed |
| US-5552557-A | Process for preparing 2-cyanoimidazole compounds by reaction of an amino ketone compound | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1996-09-03 | — | — | US | disclosed |
| EP-0653421-A1 | Process for preparing 2-cyanoimidazole compounds | ISHIHARA SANGYO KAISHA LTD. (JP) | 1995-05-17 | — | — | EP | disclosed |
| US-4968702-A | ANTIARTHRITIC, INHIBITORS OF PROGRESSIVE JOINT DETERIORATION, IMMUNOSUPPRESSANT | AMERICAN CYANAMID COMPANY (US) | 1990-11-06 | — | — | US | disclosed |
| EP-0379145-A2 | Substituted quinolinecarboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1990-07-25 | — | — | EP | disclosed |