Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA4 | P22748 | 5/20 | 0.46 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL11355201 | 1.00 | CA1 (0.55) | CA1CA4FAHD1LMNAFFAR3 | |
| Bicarbonate SCHEMBL10706072 | 0.89 | — | — | |
| Bicarbonate SCHEMBL9861044 | 0.89 | CA1 (0.55) | CA1CA4FAHD1LMNAFFAR3 | |
| Bicarbonate SCHEMBL28580172 | 0.88 | CA4 (0.50) | CA1CA4FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL1183 | 0.88 | — | — | |
| Bicarbonate SCHEMBL6337683 | 0.88 | CA4 (0.50) | CA1CA4FAHD1LMNAMEN1 | |
| Acetic Acid SCHEMBL9302865 | 0.84 | CA1 (0.80) | CA1CA4FAHD1LMNAFFAR3 | |
| Bicarbonate SCHEMBL8745022 | 0.84 | — | — | |
| Bicarbonate SCHEMBL5076875 | 0.84 | — | — | |
| Bicarbonate SCHEMBL2236803 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0605768-B1 | Storage stable solution of carbonated magnesiummethoxide in methanol, preparation and use | HUELS CHEMISCHE WERKE AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| EP-0605768-A1 | Storage stable solution of carbonated magnesiummethoxide in methanol, preparation and use | HÜLS AKTIENGESELLSCHAFT (DE) | 1994-07-13 | — | — | EP | disclosed |