Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alloxazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 5/20 | 0.81 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.81 |
| ▸ | CASP7 | P55210 | 3/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.81 |
| ▸ | RAB9A | P51151 | 2/20 | 0.81 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.81 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.81 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.81 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.81 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.81 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.81 |
| ▸ | POLB | P06746 | 5/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | PKM | P14618 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alloxazine SCHEMBL29516835 | 0.90 | KDM4E (1.00) | BLMTDP1KDM4ECASP7ALDH1A1 | |
| Alloxazine SCHEMBL499075 | 0.90 | KDM4E (1.00) | BLMTDP1KDM4ECASP7ALDH1A1 | |
| Alloxazine SCHEMBL9619177 | 0.89 | KDM4E (0.96) | BLMTDP1KDM4ECASP7ALDH1A1 | |
| SCHEMBL23908716 | 0.79 | KDM4E (0.77) | BLMTDP1KDM4ECASP7ALDH1A1 | |
| SCHEMBL29373310 | 0.78 | TDP1 (0.62) | BLMTDP1KDM4ECASP7ALDH1A1 | |
| SCHEMBL18048102 | 0.78 | TDP1 (0.62) | BLMTDP1KDM4ECASP7ALDH1A1 | |
| SCHEMBL18048112 | 0.78 | TDP1 (0.62) | BLMTDP1KDM4ECASP7ALDH1A1 | |
| SCHEMBL18048095 | 0.78 | TDP1 (0.62) | BLMTDP1KDM4ECASP7ALDH1A1 | |
| SCHEMBL11087373 | 0.78 | KDM4E (0.69) | BLMTDP1KDM4ECASP7ALDH1A1 | |
| SCHEMBL10077253 | 0.77 | MAPT (1.00) | BLMTDP1KDM4ECASP7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0756704-A1 | METHOD OF DETECTING THE PERMEABILITY OF AN OBJECT TO OXYGEN | W.R. Grace & Co.-Conn. (US) | 1997-02-05 | — | — | EP | disclosed |
| US-5583047-A | DISPERSING REDOX INDICATOR IN EXTRUDABLE CARRIER WHICH IS PLACED ON ARTICLE TO BE TESTED, THEN PHOTOREDUCING INDICATOR TO REMOVE RESIDUAL OXYGEN, CONTROLLED EXPOSURE TO OXYGEN AND ILLUMINATION FOR VISUALIZATION | W. R. GRACE & CO.-CONN. (US) | 1996-12-10 | — | — | US | disclosed |
| WO-1995029394-A1 | METHOD OF DETECTING THE PERMEABILITY OF AN OBJECT TO OXYGEN | W.R. GRACE & CO.-CONN. (US) | 1995-11-02 | — | — | WO | disclosed |