SCHEMBL8745733

SCHEMBL8745733

Nc1cc(Cl)cc2c1C(=O)c1ccccc1C2=O

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 3/20 0.60
MAOA P21397 2/20 0.55
CSNK1A1 P48729 2/20 0.55
CSNK1D P48730 2/20 0.55
CSNK1G1 Q9HCP0 2/20 0.55
FGR P09769 1/20 0.55
PIM1 P11309 1/20 0.55
DYRK1A Q13627 1/20 0.55
HIPK2 Q9H2X6 1/20 0.55
MAOB P27338 1/20 0.52
S100A4 P26447 1/20 0.50
MEN1 O00255 6/20 0.49
KMT2A Q03164 6/20 0.49
MAPT P10636 4/20 0.49
TDP1 Q9NUW8 4/20 0.49
POLB P06746 4/20 0.49
CYP1A1 P04798 1/20 0.49
CYP1A2 P05177 1/20 0.49
MCL1 Q07820 5/20 0.47
MAPK1 P28482 4/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10702044 0.86 HSP90AA1 (0.42) ADORA2AMAOACSNK1A1CSNK1DCSNK1G1
SCHEMBL8773163 0.82 ADORA2A (0.62) ADORA2AMAOACSNK1A1CSNK1DCSNK1G1
SCHEMBL29494860 0.82 ADORA2A (0.62) ADORA2AMAOACSNK1A1CSNK1DCSNK1G1
SCHEMBL9846520 0.81 ELANE (0.53) ADORA2AMAOAMAOBS100A4MEN1
SCHEMBL6905214 0.80 TTR (0.64) ADORA2AMAOACSNK1A1CSNK1DCSNK1G1
SCHEMBL8777813 0.79 ADORA2A (0.58) ADORA2AMAOACSNK1A1CSNK1DCSNK1G1
SCHEMBL28097581 0.79 MCL1 (0.68) ADORA2AMAOACSNK1A1CSNK1DCSNK1G1
SCHEMBL29191819 0.79 TTR (0.58) ADORA2AMAOACSNK1A1CSNK1DCSNK1G1
SCHEMBL8777815 0.79 ADORA2A (0.68) ADORA2AMAOACSNK1A1CSNK1DCSNK1G1
SCHEMBL9846592 0.79 ADORA2A (0.68) ADORA2AMAOACSNK1A1CSNK1DCSNK1G1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-6080648-A None JP disclosed
EP-2895561-B1 INKS AND A PROCESS FOR INK-JET PRINTING TEXTILE FIBRE MATERIALS HUNTSMAN ADVANCED MAT (SWITZERLAND) GMBH (CH) 2017-09-20 EP disclosed
CN-105585875-A Dication active dye for salt-free dyeing of cotton fabrics and preparation method thereof NANJING UNIVERSITY OF TECHNOLOGY 2016-05-18 CN disclosed
EP-0585873-B1 Method of preparing disazo pigments CLARIANT GMBH (DE) 1997-12-29 EP disclosed
EP-0576996-B1 Method of preparation of 7,16-dichloro-dianthraquinone-N,N'-dihydroazine BASF AG (DE) 1997-02-12 EP disclosed
US-5559216-A AZO COUPLING HOECHST AG (DE) 1996-09-24 US disclosed
US-5493011-A PIGMENTING HIGH MOLECULAR WEIGHT NATURAL OR SYNTHETIC ORGANIC MATERIALS HOECHST AG (DE) 1996-02-20 US disclosed
US-5367074-A Preparation of 7,16-dichlorodianthraquinone-N,N'-dihydroazine BASF AKTIENGESELLSCHAFT (DE) 1994-11-22 US disclosed
EP-0518909-B1 WATER-INSOLUBLE AZO DYES, THEIR MANUFACTURE AND USE HOECHST AG (DE) 1994-05-25 EP disclosed
JP-H0680648-A PREPARATION OF 7,16-DICHLORO-DIANTHRAQUINONE-N,N'-DIHYDROAZINE BASF AG 1994-03-22 JP disclosed
EP-0019285-B1 PROCESS FOR PREPARING ASYMMETRICAL VAT DYESTUFFS OF THE ANTHRAQUINONE SERIES AND THEIR USE IN DYEING AND PRINTING CIBA-GEIGY AG (CH) 1984-05-09 EP disclosed
US-4329456-A ACYLATION WITHOUT INTERMEDIATE ISOLATION CIBA-GEIGY AG (CH) 1982-05-11 US disclosed
US-4284770-A DEHALOGENATION, HYDRAZINE COMPOUND CIBA-GEIGY CORPORATION (US) 1981-08-18 US disclosed
US-4261909-A Process for the reductive removal of halogen atoms from anthraquinones CIBA-GEIGY AG (CH) 1981-04-14 US disclosed
EP-0019285-A1 Process for preparing asymmetrical vat dyestuffs of the anthraquinone series and their use in dyeing and printing CIBA-GEIGY AG (CH) 1980-11-26 EP disclosed
EP-0002041-A1 Processes for synthesizing bisazomethine-bisazo pigments CIBA-GEIGY AG (CH) 1979-05-30 EP disclosed
US-4001170-A ANTHRAPYRIMIDINES CIBA-GEIGY CORPORATION (US) 1977-01-04 US disclosed
US-3972881-A VAT, CELLULOSE CIBA-GEIGY CORPORATION (US) 1976-08-03 US disclosed
US-3953420-A Azo pigments derived from 2-hydroxy-3-carboxynaphthalene containing a substituted or unsubstituted phthalimide BADISCHE ANILIN- & SODA-FABRIK AKTIENGESELLSCHAFT (DT) 1976-04-27 US disclosed
US-3935208-A NATURAL OR REGENERATED CELLULOSE ALTERMATT HANS 1976-01-27 US disclosed