SCHEMBL8747876

SCHEMBL8747876

CCCCCC1CCC(c2ccc(CCc3ccc(C(F)(F)F)c(F)c3)c(F)c2)CC1

nearest known ligand 0.38

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SPHK1 Q9NYA1 11/20 0.37
KDM1A O60341 1/20 0.36
DAO P14920 1/20 0.35
POLQ O75417 1/20 0.34
S1PR1 P21453 1/20 0.33
SPHK2 Q9NRA0 7/20 0.33
CYP3A4 P08684 1/20 0.32
CYP2C8 P10632 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
S1PR3 Q99500 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8747966 0.99 SPHK1 (0.39) SPHK1KDM1ADAOPOLQSPHK2
SCHEMBL8747929 0.99 SPHK1 (0.39) SPHK1KDM1ADAOPOLQSPHK2
SCHEMBL8747905 0.97 KDM1A (0.36) SPHK1KDM1ADAOPOLQS1PR1
SCHEMBL8748215 0.93 KDM1A (0.38) SPHK1KDM1ADAOPOLQCYP2C9
SCHEMBL8108873 0.88 KDM1A (0.44) SPHK1KDM1APOLQCYP3A4CYP2C8
SCHEMBL8043804 0.88 KDM1A (0.34) KDM1ADAOPOLQ
SCHEMBL8748217 0.87 SPHK1 (0.36) SPHK1DAOSPHK2CYP2C9
SCHEMBL8748038 0.87 SPHK1 (0.41) SPHK1SPHK2
SCHEMBL9399567 0.87 SPHK1 (0.49) SPHK1S1PR1SPHK2S1PR3
SCHEMBL8747996 0.86 SPHK1 (0.43) SPHK1SPHK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0761799-A1 Liquid crystalline compound substituted with fluorine containing group, liquid crystal composition, and liquid crystal display device Chisso Corporation (JP) 1997-03-12 EP disclosed