SCHEMBL8748005

SCHEMBL8748005

CCCC1CCC(c2ccc(CCc3ccc(OC(F)(F)F)cc3)c(F)c2)CC1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 1/20 0.38
ALDH1A1 P00352 2/20 0.36
LMNA P02545 1/20 0.36
MAPT P10636 1/20 0.36
KDM1A O60341 1/20 0.36
RCOR1 Q9UKL0 1/20 0.36
MEN1 O00255 1/20 0.36
MAPK1 P28482 1/20 0.36
KMT2A Q03164 1/20 0.36
TSHR P16473 1/20 0.36
DAO P14920 1/20 0.36
GCGR P47871 1/20 0.35
EPHX2 P34913 1/20 0.35
SLC6A4 P31645 4/20 0.35
SLC6A3 Q01959 4/20 0.35
GPR84 Q9NQS5 1/20 0.34
HCRTR1 O43613 1/20 0.34
HCRTR2 O43614 1/20 0.34
CCNA2 P20248 1/20 0.34
CDK2 P24941 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8748035 0.94 SPHK1 (0.37) KDM1ARCOR1TSHRDAOEPHX2
SCHEMBL8747945 0.93 SPHK1 (0.39) KDM1ARCOR1TSHRDAOSPHK1
SCHEMBL8748080 0.92 SPHK1 (0.40) KDM1ARCOR1TSHRSPHK1FFAR4
SCHEMBL8748059 0.92 SPHK1 (0.40) KDM1ARCOR1TSHRSPHK1FFAR4
SCHEMBL14274432 0.91 SLC6A4 (0.39) CYP2C9ALDH1A1LMNAMAPTKDM1A
SCHEMBL9060236 0.88 CYP2C9 (0.47) CYP2C9ALDH1A1LMNAMAPTKDM1A
SCHEMBL9060233 0.88 CYP2C9 (0.47) CYP2C9ALDH1A1LMNAMAPTKDM1A
SCHEMBL8031354 0.88 CYP2C9 (0.36) CYP2C9ALDH1A1LMNAMAPTMEN1
SCHEMBL8747864 0.88 CYP2C9 (0.37) CYP2C9ALDH1A1LMNAMAPTMEN1
SCHEMBL8048753 0.88 EPHX2 (0.34) KDM1ARCOR1TSHRDAOEPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0761799-A1 Liquid crystalline compound substituted with fluorine containing group, liquid crystal composition, and liquid crystal display device Chisso Corporation (JP) 1997-03-12 EP disclosed