Sugi Predict

Sugi Predict / Compounds / SCHEMBL8748128

SCHEMBL8748128

SCHEMBL8748128

COc1ccc(CN(C(C)=O)C(=O)C(Cc2c[nH]c3ccccc23)NC(=O)CN2CCC(N3CCCCC3)CC2)cc1OC

nearest known ligand 0.64

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ TACR1 P25103 18/20 0.64
▸ KMT2A Q03164 1/20 0.48
▸ BRS3 P32247 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7743129 0.94 TACR1 (0.64) TACR1KMT2A
SCHEMBL7743176 0.93 TACR1 (0.64) TACR1BRS3
SCHEMBL7742353 0.92 TACR1 (0.58) TACR1BRS3
SCHEMBL7742399 0.92 TACR1 (0.62) TACR1KMT2ABRS3
SCHEMBL7737692 0.91 TACR1 (0.75) TACR1
SCHEMBL7737676 0.90 TACR1 (0.59) TACR1BRS3
SCHEMBL7743779 0.90 TACR1 (0.59) TACR1BRS3
SCHEMBL7745676 0.90 TACR1 (0.64) TACR1BRS3
SCHEMBL7743755 0.89 TACR1 (0.60) TACR1BRS3
SCHEMBL7742314 0.89 TACR1 (0.60) TACR1BRS3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0761220-A1 2-Acylaminopropanamides as growth hormone secretagogues ELI LILLY AND COMPANY (US) 1997-03-12 — — EP disclosed
WO-1997006803-A1 2-ACYLAMINOPROPANAMIDES AS GROWTH HORMONE SECRETAGOGUES ELI LILLY AND COMPANY (US) 1997-02-27 — — WO disclosed
US-5565568-A USEFUL IN TREATMENT OR PREVENTION OF A PHYSIOLOGICAL DISORDER ASSOCIATED WITH AN EXCESS OF TACHYKININS ELI LILLY AND COMPANY (US) 1996-10-15 — — US disclosed