Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.50 |
| ▸ | PDE4A | P27815 | 11/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8684364 | 0.89 | PDE4B (0.50) | KMT2APDE4DPDE4BPDE4APDE4C | |
| SCHEMBL2425023 | 0.80 | MAPT (0.68) | KMT2AMAPTTDP1POLB | |
| SCHEMBL30466426 | 0.80 | MAPT (0.68) | KMT2AMAPTTDP1POLB | |
| SCHEMBL27906537 | 0.79 | PDE4A (0.46) | PDE4DPDE4BPDE4APDE4CPOLB | |
| SCHEMBL3680848 | 0.79 | PDE4D (0.54) | KMT2APDE4DPDE4BPDE4APDE4C | |
| SCHEMBL6876868 | 0.79 | PDE4A (0.44) | KMT2APDE4DPDE4BPDE4APDE4C | |
| SCHEMBL31535282 | 0.78 | KMT2A (0.50) | KMT2APDE4DPDE4BPDE4APDE4C | |
| SCHEMBL3634070 | 0.78 | KMT2A (0.50) | KMT2APDE4DPDE4BPDE4APDE4C | |
| SCHEMBL3677096 | 0.77 | PDE4D (0.49) | KMT2APDE4DPDE4BPDE4APDE4C | |
| SCHEMBL4364149 | 0.77 | PDE4B (0.53) | KMT2APDE4DPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0607373-B1 | TRISUBSTITUTED PHENYL DERIVATIVES AS SELECTIVE PHOSPHODIESTERASE IV INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 1997-03-19 | — | — | EP | disclosed |
| US-5340827-A | Phenylcarboxamide compounds which have useful pharmaceutical activity | CELLTECH, LIMITED (GB) | 1994-08-23 | — | — | US | disclosed |