SCHEMBL8750427

SCHEMBL8750427

COCc1ccc(C(C)(C)c2ccccc2)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 4/20 0.55
ESR2 Q92731 4/20 0.55
ALDH1A1 P00352 3/20 0.55
CYP3A4 P08684 2/20 0.55
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47
SMN1; SMN2 Q16637 2/20 0.46
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
KDM4E B2RXH2 4/20 0.42
LMNA P02545 1/20 0.42
NR3C2 P08235 3/20 0.42
AR P10275 1/20 0.41
HPGD P15428 1/20 0.41
TSHR P16473 1/20 0.41
SLC6A2 P23975 1/20 0.41
SLC6A4 P31645 1/20 0.41
HTR6 P50406 1/20 0.41
ESRRG P62508 1/20 0.41
SLC6A3 Q01959 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10601214 0.92 ESR1 (0.48) ESR1ESR2ALDH1A1CYP3A4NPC1
SCHEMBL20999110 0.86 POLB (0.40) ESR1ESR2ALDH1A1CYP3A4TSHR
SCHEMBL20795016 0.85 ESR1 (0.50) ESR1ESR2ALDH1A1CYP3A4NPC1
SCHEMBL17429497 0.84 AGXT (0.47) ESR1ESR2ALDH1A1CYP3A4NPC1
SCHEMBL13497082 0.82 ESR1 (0.45) ESR1ESR2ALDH1A1CYP3A4NPC1
SCHEMBL18984736 0.82 APP (0.42) ESR1ESR2ALDH1A1CYP3A4NPC1
SCHEMBL780050 0.79 APP (0.53) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL794 0.78
SCHEMBL7535051 0.78 ESR1 (0.75) ESR1ESR2ALDH1A1CYP3A4SMN1; SMN2
SCHEMBL1681364 0.77 SMN1; SMN2 (0.60) ESR1ESR2ALDH1A1CYP3A4NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0523697-B1 Color-developing compositions and their use MITSUI TOATSU CHEMICALS (JP) 1997-04-02 EP disclosed
EP-0268878-B1 Salicylic acid copolymers and their metal salts, production process thereof, color-developing agents comprising metal salts of the copolymers and color-developing sheets employing the agents MITSUI TOATSU CHEMICALS (JP) 1996-01-31 EP disclosed
US-5447901-A Color-developing sheet: base material coated with composition of /a/ multivalent metal-modified salicylic acid resin formed from salicylic acid, a benzyl compound and optional styrene and /b/ analogous resin free of salicylic acid MITSUI TOATSU CHEMICAL, INC. (JP) 1995-09-05 US disclosed
US-5376615-A Pressure sensitive elements containing a salicylic acid resin and a phenolic resin MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1994-12-27 US disclosed
EP-0523697-A1 Color-developing compositions and their use MITSUI TOATSU CHEMICALS, Inc. (JP) 1993-01-20 EP disclosed
US-5023366-A Reacted with a benzyl halide, alcohol or ether; for pressure sensitive elements MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1991-06-11 US disclosed
EP-0268878-A2 Salicylic acid copolymers and their metal salts, production process thereof, color-developing agents comprising metal salts of the copolymers and color-developing sheets employing the agents MITSUI TOATSU CHEMICALS, Inc. (JP) 1988-06-01 EP disclosed