Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.68 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.57 |
| ▸ | ALPI | P09923 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | XIAP | P98170 | 1/20 | 0.56 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.56 |
| ▸ | DPP4 | P27487 | 4/20 | 0.56 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.56 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.56 |
| ▸ | FAP | Q12884 | 1/20 | 0.56 |
| ▸ | AKT1 | P31749 | 3/20 | 0.55 |
| ▸ | PLAU | P00749 | 1/20 | 0.55 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.55 |
| ▸ | AKT2 | P31751 | 1/20 | 0.55 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL368452 | 0.95 | HDAC8 (0.69) | HDAC8DPP7ALPIPKMPTGS1 | |
| SCHEMBL1619160 | 0.95 | HDAC8 (0.69) | HDAC8DPP7ALPIPKMPTGS1 | |
| SCHEMBL1040335 | 0.95 | HDAC8 (0.69) | HDAC8DPP7ALPIPKMPTGS1 | |
| SCHEMBL1039399 | 0.94 | HDAC8 (0.68) | HDAC8DPP7ALPIPKMPTGS1 | |
| SCHEMBL8077871 | 0.94 | HDAC8 (0.68) | HDAC8DPP7ALPIPKMPTGS1 | |
| Trifluoroacetic Acid SCHEMBL5406881 | 0.88 | HDAC8 (0.61) | HDAC8DPP7DPP4DPP8DPP9 | |
| Trifluoroacetic Acid SCHEMBL6350937 | 0.87 | HDAC8 (0.59) | HDAC8DPP7DPP4DPP8DPP9 | |
| SCHEMBL10305133 | 0.86 | DPP4 (0.70) | HDAC8DPP7DPP4DPP8DPP9 | |
| SCHEMBL7506193 | 0.86 | DPP4 (0.70) | HDAC8DPP7DPP4DPP8DPP9 | |
| SCHEMBL6161206 | 0.86 | HDAC8 (0.66) | HDAC8ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0764151-A2 | PURIFICATION OF SERINE PROTEASE AND SYNTHETIC INHIBITORS THEREOF | UNIVERSITAIRE INSTELLING ANTWERPEN (BE) | 1997-03-26 | — | — | EP | disclosed |
| WO-1995034538-A2 | PURIFICATION OF SERINE PROTEASES AND SYNTHETIC INHIBITORS THEREOF | UNIVERSITAIRE INSTELLING ANTWERPEN (BE) | 1995-12-21 | — | — | WO | disclosed |