Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 13/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 12/20 | 0.41 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.39 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8752200 | 1.00 | HDAC6 (0.42) | HDAC6HDAC1HDAC4HSP90AB1HSP90AA1 | |
| SCHEMBL9176450 | 0.87 | HDAC6 (0.46) | HDAC6HDAC1HDAC4HSP90AB1HSP90AA1 | |
| SCHEMBL6004037 | 0.82 | HSP90AB1 (0.42) | HDAC6HDAC1HDAC4HSP90AB1HSP90AA1 | |
| SCHEMBL6004500 | 0.82 | HSP90AB1 (0.42) | HDAC6HDAC1HDAC4HSP90AB1HSP90AA1 | |
| SCHEMBL8752184 | 0.78 | HSP90AB1 (0.43) | HDAC6HDAC1HDAC4HSP90AB1HSP90AA1 | |
| SCHEMBL6004535 | 0.78 | HSP90AB1 (0.41) | HDAC6HDAC1HDAC4HSP90AB1HSP90AA1 | |
| SCHEMBL8752233 | 0.78 | HSP90AB1 (0.43) | HDAC6HDAC1HDAC4HSP90AB1HSP90AA1 | |
| SCHEMBL17254507 | 0.77 | HSP90AB1 (0.46) | HDAC6HDAC1HDAC4HSP90AB1HSP90AA1 | |
| SCHEMBL14244312 | 0.77 | HSP90AB1 (0.46) | HDAC6HDAC1HDAC4HSP90AB1HSP90AA1 | |
| SCHEMBL6002747 | 0.77 | HSP90AB1 (0.42) | HDAC6HDAC1HDAC4HSP90AB1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696263-A | Antiviral acyclic phosphonomethoxyalkylsubstituted alkenyl and alkynyl purine and pyrimidine derivatives | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1997-12-09 | — | — | US | disclosed |
| EP-0630381-B1 | ANTIVIRAL ACYCLIC PHOSPHONOMETHOXYALKYL SUBSTITUTED, ALKENYL AND ALKYNYL PURINE AND PYRIMIDINE DERIVATIVES | ACAD OF SCIENCE CZECH REPUBLIC (CZ) | 1997-04-09 | — | — | EP | disclosed |
| WO-1993007157-A1 | ANTIVIRAL ACYCLIC PHOSPHONOMETHOXYALKYL SUBSTITUTED, ALKENYL AND ALKYNYL PURINE AND PYRIMIDINE DERIVATIVES | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OFTHE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1993-04-15 | — | — | WO | disclosed |