Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.59 |
| ▸ | MEN1 | O00255 | 7/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | ANPEP | P15144 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12757443 | 0.85 | KMT2A (0.63) | KMT2AMEN1GAASMN1; SMN2PKM | |
| SCHEMBL15338749 | 0.84 | KMT2A (0.63) | KMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL30956341 | 0.82 | MEN1 (0.59) | KMT2AMEN1GAASMN1; SMN2PKM | |
| SCHEMBL11737517 | 0.82 | KMT2A (0.59) | KMT2AMEN1GAASMN1; SMN2PKM | |
| SCHEMBL22221161 | 0.82 | KMT2A (0.59) | KMT2AMEN1GAASMN1; SMN2PKM | |
| SCHEMBL12884451 | 0.81 | KMT2A (0.55) | KMT2AMEN1GAASMN1; SMN2PKM | |
| SCHEMBL5016485 | 0.81 | KMT2A (0.62) | KMT2AMEN1GAASMN1; SMN2PKM | |
| SCHEMBL10954350 | 0.80 | KMT2A (0.61) | KMT2AMEN1GAASMN1; SMN2PKM | |
| SCHEMBL19763089 | 0.80 | KMT2A (0.61) | KMT2AMEN1GAASMN1; SMN2PKM | |
| SCHEMBL3755675 | 0.80 | KMT2A (0.61) | KMT2AMEN1GAASMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0473225-B1 | Process for iodinating or brominating the alpha-methylenic carbon of a 3-oxo-4aza-steroid | MERCK & CO INC (US) | 1997-07-09 | — | — | EP | disclosed |
| US-5120847-A | Chemical intermediate which can be dehydrohalogenation | MERCK & CO., INC. (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0473225-A2 | Process for iodinating or brominating the alpha-methylenic carbon of a secondary amide | MERCK & CO. INC. (US) | 1992-03-04 | — | — | EP | disclosed |