Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 3/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.34 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.34 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.30 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.30 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8767655 | 1.00 | GRIK1 (0.34) | GRIK1GRIA2GRIA4GRIK3GRIK5 | |
| SCHEMBL23741945 | 0.77 | PLAU (0.33) | — | |
| SCHEMBL8518713 | 0.76 | KDM4E (0.33) | GRIK1GRIA2GRIA4GRIK3GRIK5 | |
| SCHEMBL10542865 | 0.76 | GRIK1 (0.36) | GRIK1GRIA2GRIA4GRIK3GRIK5 | |
| SCHEMBL6671690 | 0.75 | — | — | |
| SCHEMBL9651313 | 0.75 | — | — | |
| SCHEMBL74358 | 0.74 | GRIK1 (0.31) | GRIK1GRIA2GRIA4GRIK3GRIK5 | |
| SCHEMBL74357 | 0.74 | GRIK1 (0.31) | GRIK1GRIA2GRIA4GRIK3GRIK5 | |
| SCHEMBL7322804 | 0.73 | — | — | |
| Bicarbonate SCHEMBL2054039 | 0.73 | FFAR3 (0.32) | CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4421854-A | MUTANT OF ARTHROBACTER | W. R. GRACE & CO. (US) | 1983-12-20 | — | — | US | claimed |
| EP-0787010-A1 | AMIDINO AND GUANIDINO SUBSTITUTED INHIBITORS OF TRYPSIN-LIKE ENZYMES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-08-06 | — | — | EP | disclosed |
| US-4421854-A | MUTANT OF ARTHROBACTER | W. R. GRACE & CO. (US) | 1983-12-20 | — | — | US | disclosed |