Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4826210 | 0.88 | PDE4A (0.63) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL1387380 | 0.78 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL1387378 | 0.78 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL1387472 | 0.78 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6755361 | 0.77 | PDE4A (0.95) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL71739 | 0.76 | PDE4A (0.77) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL4824641 | 0.76 | PDE4A (0.72) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7900923 | 0.76 | PDE4A (0.66) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL4818633 | 0.76 | PDE4A (0.72) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6251077 | 0.76 | PDE4A (0.92) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640070-B1 | STYRYL DERIVATIVES, THEIR PREPARATION AND USE AS PDE-IV INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 1997-09-10 | — | — | EP | disclosed |
| US-5633257-A | PHOSPHODIESTERASE INHIBITOR | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-05-27 | — | — | US | disclosed |