Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 12/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.53 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.53 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8862774 | 0.99 | PDE4A (0.53) | PDE4APDE4BPDE4DPDE4CS1PR1 | |
| Nitrous Acid SCHEMBL7175057 | 0.94 | PDE4B (0.52) | PDE4APDE4BPDE4DPDE4CS1PR1 | |
| SCHEMBL7323473 | 0.89 | PDE4A (0.51) | PDE4APDE4BPDE4DPDE4CS1PR1 | |
| SCHEMBL7323469 | 0.89 | PDE4A (0.51) | PDE4APDE4BPDE4DPDE4CS1PR1 | |
| SCHEMBL4825142 | 0.87 | PDE4B (0.55) | PDE4APDE4BPDE4DPDE4CMAPK14 | |
| SCHEMBL4826823 | 0.87 | PDE4A (0.59) | PDE4APDE4BPDE4DPDE4CS1PR1 | |
| SCHEMBL8269320 | 0.87 | PDE4D (0.61) | PDE4APDE4BPDE4DPDE4CMAPK14 | |
| SCHEMBL7314291 | 0.86 | PDE4A (0.53) | PDE4APDE4BPDE4DPDE4CS1PR1 | |
| SCHEMBL4825447 | 0.86 | PDE4B (0.56) | PDE4APDE4BPDE4DPDE4CMAPK14 | |
| SCHEMBL7310472 | 0.85 | PDE4A (0.49) | PDE4APDE4BPDE4DPDE4CS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640070-B1 | STYRYL DERIVATIVES, THEIR PREPARATION AND USE AS PDE-IV INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 1997-09-10 | — | — | EP | disclosed |
| US-5633257-A | PHOSPHODIESTERASE INHIBITOR | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-05-27 | — | — | US | disclosed |