Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 19/20 | 0.84 |
| ▸ | HDAC3 | O15379 | 18/20 | 0.84 |
| ▸ | HDAC4 | P56524 | 18/20 | 0.84 |
| ▸ | HDAC1 | Q13547 | 18/20 | 0.84 |
| ▸ | HDAC7 | Q8WUI4 | 18/20 | 0.84 |
| ▸ | HDAC2 | Q92769 | 18/20 | 0.84 |
| ▸ | HDAC10 | Q969S8 | 18/20 | 0.84 |
| ▸ | HDAC11 | Q96DB2 | 18/20 | 0.84 |
| ▸ | HDAC6 | Q9UBN7 | 18/20 | 0.84 |
| ▸ | HDAC9 | Q9UKV0 | 18/20 | 0.84 |
| ▸ | HDAC5 | Q9UQL6 | 18/20 | 0.84 |
| ▸ | BRD4 | O60885 | 1/20 | 0.72 |
| ▸ | ESR1 | P03372 | 1/20 | 0.72 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.72 |
| ▸ | PDE4A | P27815 | 1/20 | 0.72 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.72 |
| ▸ | HTR6 | P50406 | 1/20 | 0.72 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.72 |
| ▸ | ASPH | Q12797 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8770042 | 1.00 | HDAC8 (0.84) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1403249 | 0.91 | HDAC8 (1.00) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1403252 | 0.91 | HDAC8 (1.00) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8769430 | 0.87 | HDAC1 (0.82) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8769437 | 0.87 | HDAC1 (0.82) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1403553 | 0.84 | HDAC1 (1.00) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1403555 | 0.84 | HDAC1 (1.00) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| Belinostat SCHEMBL29712104 | 0.84 | HDAC1 (1.00) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| Belinostat SCHEMBL29379950 | 0.84 | HDAC1 (1.00) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL26961093 | 0.84 | HDAC3 (0.58) | HDAC8HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0570594-B1 | HYDROXAMIC ACID DERIVATIVE BASED ON AROMATIC SULFONAMIDE | SHIONOGI & CO (JP) | 1997-07-30 | — | — | EP | disclosed |
| US-5534654-A | ANTITUMOR, ANTIINFLAMMATORY, INHIBITOR OF LYMPHOCYTE ADHESIVE FACTORS | SHIONOGI & CO., LTD. (JP) | 1996-07-09 | — | — | US | disclosed |