Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.73 |
| ▸ | GAA | P10253 | 1/20 | 0.70 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | LTA4H | P09960 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | LSS | P48449 | 2/20 | 0.56 |
| ▸ | PPARG | P37231 | 2/20 | 0.55 |
| ▸ | PPARD | Q03181 | 1/20 | 0.55 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15796970 | 0.98 | PPARA (0.71) | PPARAGAAHRH4L3MBTL1LMNA | |
| SCHEMBL1469758 | 0.95 | GAA (0.72) | PPARAGAAHRH4L3MBTL1LMNA | |
| SCHEMBL11485988 | 0.93 | PPARA (0.83) | PPARAGAAHRH4L3MBTL1LMNA | |
| SCHEMBL10795926 | 0.91 | GAA (0.72) | PPARAGAAHRH4L3MBTL1LMNA | |
| SCHEMBL2127003 | 0.91 | PPARA (0.81) | PPARAGAAHRH4L3MBTL1LMNA | |
| SCHEMBL6652325 | 0.91 | PPARA (0.81) | PPARAGAAHRH4L3MBTL1LMNA | |
| SCHEMBL14689477 | 0.91 | PPARA (0.81) | PPARAGAAHRH4L3MBTL1LMNA | |
| SCHEMBL20624042 | 0.91 | PPARA (0.81) | PPARAGAAHRH4L3MBTL1LMNA | |
| SCHEMBL2127341 | 0.91 | PPARA (0.81) | PPARAGAAHRH4L3MBTL1LMNA | |
| SCHEMBL7114335 | 0.91 | PPARA (0.81) | PPARAGAAHRH4L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1167437-A | Method of using triaryl-ethylene derivatives in the treatment and prevention of osteoporosis | HOECHST MARION ROUSSEL INC (US) | 1997-12-10 | — | — | CN | disclosed |
| US-5693674-A | Method of using triaryl-ethylene derivatives in the treatment and prevention of osteoporosis | HOECHST MARION ROUSSEL, INC. (US) | 1997-12-02 | — | — | US | disclosed |
| US-5691384-A | Method of using triaryl-ethylene derivatives in the treatment and prevention of osteoporosis | HOECHST MARION ROUSSEL, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| EP-0794771-A1 | METHOD OF USING TRIARYL-ETHYLENE DERIVATIVES IN THE TREATMENT AND PREVENTION OF OSTEOPOROSIS | HOECHST MARION ROUSSEL, INC. (US) | 1997-09-17 | — | — | EP | disclosed |
| WO-1996016646-A1 | METHOD OF USING TRIARYL-ETHYLENE DERIVATIVES IN THE TREATMENT AND PREVENTION OF OSTEOPOROSIS | HOECHST MARION ROUSSEL, INC. (US) | 1996-06-06 | — | — | WO | disclosed |