Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | IDH1 | O75874 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8770183 | 0.90 | NPC1 (0.51) | MAPTLMNAPOLBNPC1RAB9A | |
| SCHEMBL8770197 | 0.90 | NPC1 (0.51) | MAPTLMNAPOLBNPC1RAB9A | |
| SCHEMBL8770242 | 0.89 | EPHX2 (0.51) | EPHX2MAPTLMNAPOLBNPC1 | |
| SCHEMBL8770257 | 0.86 | NPC1 (0.44) | MAPTLMNAPOLBNPC1RAB9A | |
| SCHEMBL8770283 | 0.86 | NPC1 (0.46) | EPHX2MAPTLMNAPOLBNPC1 | |
| SCHEMBL8770347 | 0.84 | EPHX2 (0.51) | EPHX2MAPTLMNAPOLBNPC1 | |
| SCHEMBL22192691 | 0.82 | NPC1 (0.65) | EPHX2MAPTLMNAPOLBNPC1 | |
| SCHEMBL8377792 | 0.78 | GAA (0.52) | MAPTLMNAPOLBNPC1ALDH1A1 | |
| SCHEMBL8770227 | 0.78 | NPC1 (0.51) | MAPTPOLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8770638 | 0.78 | NPC1 (0.51) | MAPTPOLBNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0632019-B1 | Acylureas | ZENECA LTD (GB) | 1997-09-24 | — | — | EP | disclosed |
| US-5576334-A | ANTICOAGULANTS | ZENECA LIMITED (GB) | 1996-11-19 | — | — | US | disclosed |
| EP-0632019-A1 | Acylureas | ZENECA LIMITED (GB) | 1995-01-04 | — | — | EP | disclosed |