Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | FNTA | P49354 | 3/20 | 0.39 |
| ▸ | FNTB | P49356 | 3/20 | 0.39 |
| ▸ | GGPS1 | O95749 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.38 |
| ▸ | SQLE | Q14534 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8771663 | 1.00 | KMT2A (0.41) | KMT2AFNTAFNTBGGPS1ALDH1A1 | |
| SCHEMBL8771734 | 0.91 | KMT2A (0.40) | KMT2AFNTAFNTBGGPS1ALDH1A1 | |
| SCHEMBL8771631 | 0.79 | KMT2A (0.41) | KMT2AFNTAFNTBGGPS1ALDH1A1 | |
| SCHEMBL8909122 | 0.77 | KMT2A (0.48) | KMT2AFNTAFNTBALDH1A1MAPT | |
| SCHEMBL8909132 | 0.77 | KMT2A (0.48) | KMT2AFNTAFNTBALDH1A1MAPT | |
| SCHEMBL8771655 | 0.76 | GGPS1 (0.49) | GGPS1 | |
| SCHEMBL9139308 | 0.75 | KMT2A (0.53) | KMT2AFNTAFNTBGGPS1ALDH1A1 | |
| SCHEMBL8771802 | 0.75 | KMT2A (0.46) | KMT2AFNTAFNTBALDH1A1MAPT | |
| SCHEMBL8771732 | 0.75 | KDM4E (0.44) | KMT2AFNTAFNTBGGPS1ALDH1A1 | |
| SCHEMBL8771720 | 0.75 | KDM4E (0.44) | KMT2AFNTAFNTBGGPS1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686159-B1 | FARNESYL:PROTEIN TRANSFERASE INHIBITORS AS ANTICANCER AGENTS | MERRELL PHARMA INC (US) | 1997-10-08 | — | — | EP | disclosed |
| US-5665715-A | Farnesyl:protein transferase inhibitors as anticancer agents | MERRELL PHARMACEUTICALS INC. (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0686159-A1 | FARNESYL:PROTEIN TRANSFERASE INHIBITORS AS ANTICANCER AGENTS | MERRELL DOW PHARMA (US) | 1995-12-13 | — | — | EP | disclosed |