SCHEMBL8772035

CC(=O)[C@]1(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)O[C@@H](n2cc(C)c(=O)[nH]c2=O)C[C@@H]1O[Si](C)(C)C(C)(C)C

nearest known ligand 0.41

Predicted protein targets (top 6)

	gene	UniProt	supporting neighbours	confidence
▸	TOP2A	P11388	6/20	0.41

▸	NT5M	Q9NPB1	1/20	0.41

▸	RNASE1	P07998	1/20	0.40

▸	TK1	P04183	3/20	0.39

▸	HDAC1	Q13547	2/20	0.37

▸	TK2	O00142	1/20	0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL8772040	1.00	TOP2A (0.41)	TOP2ANT5MRNASE1TK1HDAC1
SCHEMBL8772065	0.92	TOP2A (0.40)	TOP2ANT5MRNASE1TK1HDAC1
SCHEMBL8772067	0.92	TOP2A (0.40)	TOP2ANT5MRNASE1TK1HDAC1
SCHEMBL5191057	0.87	TOP2A (0.41)	TOP2ANT5MRNASE1TK1TK2
SCHEMBL12942598	0.87	TOP2A (0.41)	TOP2ANT5MRNASE1TK1TK2
SCHEMBL5191053	0.87	TOP2A (0.41)	TOP2ANT5MRNASE1TK1TK2
SCHEMBL5188458	0.85	TOP2A (0.41)	TOP2ANT5MRNASE1TK1HDAC1
SCHEMBL12942597	0.85	TOP2A (0.41)	TOP2ANT5MRNASE1TK1HDAC1
SCHEMBL5188453	0.85	TOP2A (0.41)	TOP2ANT5MRNASE1TK1HDAC1
SCHEMBL15354281	0.84	TOP2A (0.40)	TOP2ANT5MRNASE1TK1HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0799834-A1	Modified nucleotides	Novartis AG (CH)	1997-10-08	—	—	EP	disclosed