Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLYCD | O95822 | 12/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31211648 | 0.83 | SMN1; SMN2 (0.59) | MLYCDMEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1312005 | 0.74 | MAPT (0.44) | MLYCDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL31211569 | 0.73 | NPC1 (0.60) | MLYCDMEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL31211559 | 0.72 | NPC1 (0.62) | MLYCDMEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3270531 | 0.72 | NPC1 (0.45) | MLYCDMEN1KMT2ATP53 | |
| SCHEMBL11070556 | 0.72 | NPC1 (0.48) | MLYCDMEN1KMT2ATP53 | |
| SCHEMBL11562137 | 0.71 | NPC1 (0.47) | MLYCDTP53 | |
| SCHEMBL11559695 | 0.71 | NPC1 (0.47) | MLYCDTP53 | |
| SCHEMBL11561291 | 0.71 | NPC1 (0.47) | MLYCDTP53 | |
| SCHEMBL11063213 | 0.71 | NPC1 (0.47) | MLYCDTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691349-A | ANTICHOLESTEROL AGENTS; ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 1997-11-25 | — | — | US | disclosed |
| EP-0654032-B1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS | ZENECA LTD (GB) | 1997-10-15 | — | — | EP | disclosed |
| EP-0654032-A1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS. | ZENECA LTD (GB) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994003451-A1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS | ZENECA LIMITED (GB) | 1994-02-17 | — | — | WO | disclosed |