SCHEMBL8772859

SCHEMBL8772859

CSC(=Nc1ccc(Cl)cc1)NC#N

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.58
SMN1; SMN2 Q16637 1/20 0.57
NOS3 P29474 4/20 0.50
NOS1 P29475 4/20 0.50
NOS2 P35228 4/20 0.50
KMT2A Q03164 3/20 0.49
CYP2D6 P10635 2/20 0.41
CYP2C19 P33261 2/20 0.41
MAPT P10636 2/20 0.41
MEN1 O00255 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2C9 P11712 1/20 0.41
HTR3E A5X5Y0 2/20 0.40
HTR3B O95264 2/20 0.40
HTR3A P46098 2/20 0.40
HTR3D Q70Z44 2/20 0.40
HTR3C Q8WXA8 2/20 0.40
SLC22A2 O15244 1/20 0.40
SLC22A1 O15245 1/20 0.40
SLC22A3 O75751 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10341394 0.83 SMN1; SMN2 (0.57) ALDH1A1SMN1; SMN2NOS3NOS1KMT2A
SCHEMBL15545332 0.83 SMN1; SMN2 (0.57) ALDH1A1SMN1; SMN2NOS3NOS1NOS2
SCHEMBL16459527 0.83 SMN1; SMN2 (0.57) ALDH1A1SMN1; SMN2NOS3NOS1NOS2
SCHEMBL13325330 0.83 SMN1; SMN2 (0.69) ALDH1A1SMN1; SMN2NOS3NOS1KMT2A
SCHEMBL3287572 0.83 SMN1; SMN2 (0.69) ALDH1A1SMN1; SMN2NOS3NOS1KMT2A
SCHEMBL3287569 0.83 SMN1; SMN2 (0.69) ALDH1A1SMN1; SMN2NOS3NOS1KMT2A
SCHEMBL10452572 0.81 SMN1; SMN2 (0.72) ALDH1A1SMN1; SMN2NOS3NOS1NOS2
SCHEMBL17393894 0.81 SMN1; SMN2 (0.56) ALDH1A1SMN1; SMN2KMT2ACYP2D6CYP2C19
SCHEMBL2969080 0.80 SMN1; SMN2 (0.51) ALDH1A1SMN1; SMN2KMT2ACYP2D6CYP2C19
SCHEMBL7978023 0.80 SMN1; SMN2 (0.57) ALDH1A1SMN1; SMN2NOS3NOS1NOS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0625967-B1 N,N'-SUBSTITUTED IMIDOCARBONIMIDIC DIAMIDES DERIVED FROM HYDROXYLAMINES JACOBUS PHARMA CO INC (US) 1997-08-27 EP disclosed
US-5322858-A Antimicrobial, antiparasitic agents JACOBUS PHARMACEUTICAL CO. INC. (US) 1994-06-21 US disclosed
WO-1993016037-A1 N,N'-SUBSTITUTED IMIDOCARBONIMIDIC DIAMIDES DERIVED FROM HYDROXYLAMINES JACOBUS PHARMACEUTICAL CO., INC. (US) 1993-08-19 WO disclosed