⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1107282 | 0.72 | — | — | |
| SCHEMBL387693 | 0.72 | — | — | |
| SCHEMBL752761 | 0.70 | — | — | |
| SCHEMBL12151324 | 0.70 | — | — | |
| SCHEMBL387305 | 0.70 | — | — | |
| SCHEMBL2047182 | 0.70 | GCGR (0.31) | — | |
| SCHEMBL3716819 | 0.67 | MAPK1 (0.32) | — | |
| SCHEMBL12370927 | 0.67 | EGFR (0.32) | — | |
| SCHEMBL8277474 | 0.67 | NPC1 (0.30) | — | |
| SCHEMBL5776849 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266711-A1 | SUBSTITUTED AMIDOBENZIMIDAZOLE DIMERS AS STING MODULATORS | Aculeus Therapeutics Pty Ltd (AU) | 2022-12-29 | — | — | WO | disclosed |
| US-10894788-B2 | Inhibitors of cyclin-dependent kinases | KINNATE BIOPHARMA INC. (US) | 2021-01-19 | — | — | US | disclosed |
| US-10759813-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2020-09-01 | — | — | US | disclosed |
| US-20200031847-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2020-01-30 | — | — | US | disclosed |
| US-9765016-B2 | S1P modulating agents | BIOGEN MA INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-9724359-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2017-08-08 | — | — | US | disclosed |
| US-9688692-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2017-06-27 | — | — | US | disclosed |
| US-20170020904-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2017-01-26 | — | — | US | disclosed |
| US-20170022219-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2017-01-26 | — | — | US | disclosed |
| US-20150065343-A1 | Acrylamide compounds for combating invertebrate pests | BASF SE (DE) | 2015-03-05 | — | — | US | disclosed |
| US-20110224137-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | MERCK SHARP & DOHME CORP. | 2011-09-15 | — | — | US | disclosed |
| US-20110224136-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | MERCK SHARP & DOHME CORP | 2011-09-15 | — | — | US | disclosed |
| WO-2009040507-A1 | SUBSTITUTED BENAMIDINES AS ANTIBACTERIAL AGENTS | PROLYSIS LTD (GB) | 2009-04-02 | — | — | WO | disclosed |
| EP-0577555-B1 | Derivatives of carboxylic acids | CIBA GEIGY AG (CH) | 1997-11-05 | — | — | EP | disclosed |
| US-5578595-A | PESTICIDES | CIBA-GEIGY CORPORATION (US) | 1996-11-26 | — | — | US | disclosed |
| US-5481013-A | INSECTICIDES, MITICIDES, CROPS | CIBA-GEIGY CORPORATION (US) | 1996-01-02 | — | — | US | disclosed |
| US-5326901-A | 3-butenoic acid derivatives as intermediates for pesticides | CIBA-GEIGY CORPORATION (US) | 1994-07-05 | — | — | US | disclosed |
| EP-0577555-A1 | Derivatives of carboxylic acids | CIBA-GEIGY AG (CH) | 1994-01-05 | — | — | EP | disclosed |
| EP-0468927-A2 | Derivatives of carboxymethylcyclopropane | CIBA-GEIGY AG (CH) | 1992-01-29 | — | — | EP | disclosed |
| EP-0467840-A2 | Derivatives of cyclopropyl acetic acid | CIBA-GEIGY AG (CH) | 1992-01-22 | — | — | EP | disclosed |