Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.89 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | SAT1 | P21673 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylamine SCHEMBL9701031 | 1.00 | TP53 (0.89) | TP53CYP2C19MEN1GLAKMT2A | |
| Diethylamine SCHEMBL27848454 | 1.00 | TP53 (0.89) | TP53CYP2C19MEN1GLAKMT2A | |
| Diethylamine SCHEMBL9701034 | 1.00 | — | — | |
| Diethylamine SCHEMBL29019634 | 1.00 | — | — | |
| Diethylamine SCHEMBL19856521 | 1.00 | TP53 (0.89) | TP53CYP2C19MEN1GLAKMT2A | |
| Diethylamine SCHEMBL2869417 | 1.00 | TP53 (0.89) | TP53CYP2C19MEN1GLAKMT2A | |
| Diethylamine SCHEMBL124914 | 1.00 | — | — | |
| Diethylamine SCHEMBL1332127 | 1.00 | — | — | |
| Diethylamine SCHEMBL5321340 | 1.00 | — | — | |
| Diethylamine SCHEMBL2163210 | 0.95 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0476671-B1 | Homogeneous catalysts for olefin polymerization | DOW CHEMICAL CO (US) | 1997-11-05 | — | — | EP | disclosed |
| EP-0745617-A2 | Olefin polymerisation process | THE DOW CHEMICAL COMPANY (US) | 1996-12-04 | — | — | EP | disclosed |
| US-5312938-A | Complexing an aminotitanium compound with an indene compound | THE DOW CHEMICAL COMPANY (US) | 1994-05-17 | — | — | US | disclosed |
| US-5194532-A | Complexes of titanium, indene derivatives and secondary amines | THE DOW CHEMICAL COMPANY (US) | 1993-03-16 | — | — | US | disclosed |
| EP-0476671-A2 | Homogeneous catalysts and olefin polymerization process | THE DOW CHEMICAL COMPANY (US) | 1992-03-25 | — | — | EP | disclosed |