Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 13/20 | 0.42 |
| ▸ | FEN1 | P39748 | 12/20 | 0.42 |
| ▸ | FASN | P49327 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | APP | P05067 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774585 | 1.00 | ALOX5AP (0.42) | ALOX5APFEN1FASNGRIN1GRIN2B | |
| SCHEMBL8774486 | 0.90 | CYP2C9 (0.40) | ALOX5APFEN1FASNGRIN1GRIN2B | |
| SCHEMBL8774493 | 0.90 | CYP2C9 (0.40) | ALOX5APFEN1FASNGRIN1GRIN2B | |
| SCHEMBL8774754 | 0.88 | GAA (0.35) | ALOX5APFEN1FASNGRIN1GRIN2B | |
| SCHEMBL8774761 | 0.88 | GAA (0.35) | ALOX5APFEN1FASNGRIN1GRIN2B | |
| SCHEMBL8774739 | 0.87 | MAPT (0.36) | ALOX5APFEN1FASNGRIN1GRIN2B | |
| SCHEMBL8774734 | 0.87 | MAPT (0.36) | ALOX5APFEN1FASNGRIN1GRIN2B | |
| SCHEMBL8774385 | 0.86 | MAPT (0.38) | ALOX5APFEN1FASNCYP3A4CYP2C9 | |
| SCHEMBL8774865 | 0.86 | MAPT (0.38) | ALOX5APFEN1FASNCYP3A4CYP2C9 | |
| SCHEMBL8774852 | 0.86 | MAPT (0.38) | ALOX5APFEN1FASNCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |