Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.35 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774946 | 1.00 | MAPT (0.38) | MAPTGAACYP2C9PDE5AMEN1 | |
| SCHEMBL8774052 | 0.99 | MAPT (0.39) | MAPTGAACYP2C9PDE5AMEN1 | |
| SCHEMBL8774553 | 0.99 | MAPT (0.39) | MAPTGAACYP2C9PDE5AMEN1 | |
| SCHEMBL8774057 | 0.99 | MAPT (0.39) | MAPTGAACYP2C9PDE5AMEN1 | |
| SCHEMBL8774562 | 0.99 | MAPT (0.39) | MAPTGAACYP2C9PDE5AMEN1 | |
| SCHEMBL8774509 | 0.96 | CYP2C9 (0.38) | MAPTGAACYP2C9PDE5AMEN1 | |
| SCHEMBL8774502 | 0.96 | CYP2C9 (0.38) | MAPTGAACYP2C9PDE5AMEN1 | |
| SCHEMBL8774544 | 0.91 | CYP2C9 (0.45) | MAPTCYP2C9MEN1KMT2AMAPK1 | |
| SCHEMBL8774551 | 0.91 | CYP2C9 (0.45) | MAPTCYP2C9MEN1KMT2AMAPK1 | |
| SCHEMBL8774739 | 0.87 | MAPT (0.36) | MAPTGAACYP2C9PDE5AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |