Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 9/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.38 |
| ▸ | BCL2 | P10415 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25600150 | 0.90 | MCL1 (0.52) | MCL1KDM4EADRA2BMAPK1ALDH1A1 | |
| SCHEMBL6835175 | 0.88 | MCL1 (0.42) | MCL1KDM4EADRA2BMAPK1ALDH1A1 | |
| SCHEMBL5434419 | 0.76 | MCL1 (0.41) | MCL1KDM4EADRA2BMAPK1CHRM1 | |
| SCHEMBL6325566 | 0.75 | MCL1 (0.43) | MCL1KDM4EMAPK1ALDH1A1HSD17B10 | |
| SCHEMBL19779451 | 0.74 | MCL1 (0.45) | MCL1KDM4EBCL2PARP1 | |
| SCHEMBL8039755 | 0.74 | HTR2A (0.49) | MCL1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL8775577 | 0.74 | PARP1 (0.45) | KDM4EADRA2BMAPK1ALDH1A1CHRM1 | |
| SCHEMBL2183758 | 0.73 | MCL1 (0.49) | MCL1KDM4ECHRM1BCL2L1LMNA | |
| SCHEMBL28182064 | 0.73 | PARP1 (0.50) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| SCHEMBL11768838 | 0.72 | KDM4E (0.42) | KDM4EADRA2BMAPK1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0529688-B1 | Azaspiro(n,m)alkanes and diazaspiro(n,m)-alkanes | DAIICHI SEIYAKU CO (JP) | 1997-11-12 | — | — | EP | disclosed |
| US-5508428-A | Spiro compound | DAIICHI PHAMACEUTICAL CO., LTD. (JP) | 1996-04-16 | — | — | US | disclosed |
| US-5286723-A | Spiro compound | DAIICHI SEIYAKU CO., LTD. | 1994-02-15 | — | — | US | disclosed |
| EP-0357047-B1 | Spiro compounds | DAIICHI SEIYAKU CO (JP) | 1993-11-03 | — | — | EP | disclosed |
| EP-0529688-A2 | Azaspiro n,m alkanes and diazaspiro n,m -alkanes | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1993-03-03 | — | — | EP | disclosed |
| US-5066802-A | Multistep process from 2,4-difluoro-3-chloronitrobenzene and mercaptoisopropanol or mercaptopropanediol | MEDIOLANUM FARMACEUTICI SRL. (IT) | 1991-11-19 | — | — | US | disclosed |
| US-4923859-A | Pyrido-benzothiazine derivatives having high antibacterial activity and high bioavailability to tissues | MEDIOLANUM FARMACEUTICI, S.R.L. (IT) | 1990-05-08 | — | — | US | disclosed |
| EP-0357047-A1 | Spiro compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1990-03-07 | — | — | EP | disclosed |