Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 5/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9676468 | 1.00 | MAPT (0.36) | MAPTNPSR1MEN1KMT2ALMNA | |
| SCHEMBL9562430 | 0.92 | NPSR1 (0.36) | MAPTNPSR1MEN1KMT2ALMNA | |
| SCHEMBL10400402 | 0.92 | NPSR1 (0.36) | MAPTNPSR1MEN1KMT2ALMNA | |
| SCHEMBL7049477 | 0.92 | NPSR1 (0.36) | MAPTNPSR1MEN1KMT2ALMNA | |
| SCHEMBL9562451 | 0.91 | POLB (0.39) | MAPTNPSR1MEN1KMT2ALMNA | |
| SCHEMBL8437121 | 0.91 | POLB (0.39) | MAPTNPSR1MEN1KMT2ALMNA | |
| SCHEMBL8437126 | 0.91 | POLB (0.39) | MAPTNPSR1MEN1KMT2ALMNA | |
| SCHEMBL10472436 | 0.91 | POLB (0.39) | MAPTNPSR1MEN1KMT2ALMNA | |
| SCHEMBL10472438 | 0.91 | POLB (0.39) | MAPTNPSR1MEN1KMT2ALMNA | |
| SCHEMBL7013263 | 0.90 | MAPT (0.34) | MAPTNPSR1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0529688-B1 | Azaspiro(n,m)alkanes and diazaspiro(n,m)-alkanes | DAIICHI SEIYAKU CO (JP) | 1997-11-12 | — | — | EP | disclosed |
| US-5508428-A | Spiro compound | DAIICHI PHAMACEUTICAL CO., LTD. (JP) | 1996-04-16 | — | — | US | disclosed |
| US-5286723-A | Spiro compound | DAIICHI SEIYAKU CO., LTD. | 1994-02-15 | — | — | US | disclosed |
| EP-0357047-B1 | Spiro compounds | DAIICHI SEIYAKU CO (JP) | 1993-11-03 | — | — | EP | disclosed |
| EP-0529688-A2 | Azaspiro n,m alkanes and diazaspiro n,m -alkanes | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1993-03-03 | — | — | EP | disclosed |
| EP-0237955-B1 | QUINOLONECARBOXYLIC ACID DERIVATIVES AND THEIR PREPARATION | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1992-07-15 | — | — | EP | disclosed |
| EP-0286089-B1 | QUINOLINECARBOXYLIC ACID DERIVATIVES, A COMPOSITION COMPRISING THE SAME, PROCESS FOR PREPARING THE SAME, AND THE USE OF THE SAME FOR THE MANUFACTURE OF MEDICAMENTS | KANEBO, LTD. (JP) | 1991-11-13 | — | — | EP | disclosed |
| EP-0357047-A1 | Spiro compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1990-03-07 | — | — | EP | disclosed |
| US-4894458-A | BACTERICIDES | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1990-01-16 | — | — | US | disclosed |
| US-4853469-A | BACTERICIDES | KANEBO, LTD. (JP) | 1989-08-01 | — | — | US | disclosed |
| US-4808584-A | Quinolinecarboxylic acid derivatives and antibacterial agent containing the same | KANEBO, LTD. (JP) | 1989-02-28 | — | — | US | disclosed |
| EP-0286089-A1 | Quinolinecarboxylic acid derivatives, a composition comprising the same, process for preparing the same, and the use of the same for the manufacture of medicaments | KANEBO, LTD. (JP) | 1988-10-12 | — | — | EP | disclosed |
| EP-0237955-A2 | Quinolonecarboxylic acid derivatives and their preparation | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1987-09-23 | — | — | EP | disclosed |