⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1860953 | 0.82 | FUCA1 (0.42) | — | |
| SCHEMBL9581672 | 0.82 | FUCA1 (0.42) | — | |
| SCHEMBL18312546 | 0.74 | — | — | |
| SCHEMBL21856847 | 0.74 | — | — | |
| SCHEMBL18456615 | 0.74 | — | — | |
| SCHEMBL22161321 | 0.74 | — | — | |
| SCHEMBL22065346 | 0.74 | — | — | |
| SCHEMBL22161352 | 0.74 | — | — | |
| SCHEMBL22161128 | 0.74 | — | — | |
| SCHEMBL3741343 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0338435-A1 | 3,4-Dihydroxypyrrolidin-2-one derivatives, process for their preparation, agents containing them and their use as well as the intermediates resulting from the preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-10-25 | — | — | EP | claimed |
| CN-118852123-A | Novel heterocyclic compounds as Pol theta inhibitors for the treatment and prevention of cancer and pharmaceutical compositions containing the same | 株式会社大熊制药 | 2024-10-29 | — | — | CN | disclosed |
| CN-110430878-A | Antitumor agent and bromine structural domain inhibitor | FUJIFILM CORP | 2019-11-08 | — | — | CN | disclosed |
| CN-108137505-A | Nitrogen-containing heterocycle compound | 富士胶片株式会社 | 2018-06-08 | — | — | CN | disclosed |
| EP-0449011-B1 | Stereoselective process for the preparation of 2-amino-ethanol derivatives having a central analgesic activity and intermediates thereof | ZAMBON SPA (IT) | 1997-10-08 | — | — | EP | disclosed |
| EP-0338435-A1 | 3,4-Dihydroxypyrrolidin-2-one derivatives, process for their preparation, agents containing them and their use as well as the intermediates resulting from the preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-10-25 | — | — | EP | disclosed |
| EP-0338435-A1 | 3,4-Dihydroxypyrrolidin-2-one derivatives, process for their preparation, agents containing them and their use as well as the intermediates resulting from the preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-10-25 | — | — | EP | disclosed |
| EP-0338435-A1 | 3,4-Dihydroxypyrrolidin-2-one derivatives, process for their preparation, agents containing them and their use as well as the intermediates resulting from the preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-10-25 | — | — | EP | disclosed |