Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 8/20 | 0.63 |
| ▸ | PDE4A | P27815 | 14/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 14/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7736318 | 0.90 | TNF (0.62) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6283968 | 0.90 | TNF (0.62) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6289224 | 0.90 | TNF (0.62) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4864210 | 0.84 | TNF (0.76) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6287593 | 0.84 | TNF (0.76) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6280398 | 0.84 | TNF (0.76) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4857889 | 0.84 | TNF (0.68) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6283989 | 0.84 | TNF (0.68) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6286847 | 0.84 | TNF (0.68) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6281501 | 0.82 | TNF (0.60) | TNFPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0800514-A1 | SUBSTITUTED IMIDES AS TNF INHIBITORS | CELGENE CORPORATION (US) | 1997-10-15 | — | — | EP | disclosed |
| WO-1996020926-A1 | SUBSTITUTED IMIDES AS TNF INHIBITORS | CELGENE CORPORATION (US) | 1996-07-11 | — | — | WO | disclosed |