Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 5/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MGAM | O43451 | 2/20 | 0.38 |
| ▸ | SI | P14410 | 2/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | PRNP | P04156 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8777026 | 0.88 | TNF (0.43) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3692514 | 0.87 | PDE4A (0.53) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8779459 | 0.86 | TNF (0.45) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8779469 | 0.85 | TNF (0.42) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8777030 | 0.83 | TNF (0.40) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7846184 | 0.83 | PDE4A (0.60) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3697869 | 0.78 | PDE4A (0.52) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7836605 | 0.78 | PDE4A (0.50) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3690301 | 0.78 | PDE4A (0.52) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL825836 | 0.76 | PDE4A (0.47) | TNFPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0800514-A1 | SUBSTITUTED IMIDES AS TNF INHIBITORS | CELGENE CORPORATION (US) | 1997-10-15 | — | — | EP | disclosed |
| WO-1996020926-A1 | SUBSTITUTED IMIDES AS TNF INHIBITORS | CELGENE CORPORATION (US) | 1996-07-11 | — | — | WO | disclosed |