Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 15/20 | 0.69 |
| ▸ | SRD5A2 | P31213 | 10/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.69 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.69 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.69 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.69 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.69 |
| ▸ | HSD3B1 | P14060 | 1/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | THPO | P40225 | 1/20 | 0.69 |
| ▸ | BLM | P54132 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8777109 | 1.00 | SRD5A1 (0.69) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| SCHEMBL8777113 | 0.94 | SRD5A1 (0.70) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| SCHEMBL8777111 | 0.94 | SRD5A1 (0.70) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| SCHEMBL8777122 | 0.94 | SRD5A1 (0.70) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| SCHEMBL8793963 | 0.89 | SRD5A1 (0.68) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| SCHEMBL8793969 | 0.89 | SRD5A1 (0.68) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| SCHEMBL8795142 | 0.89 | SRD5A1 (0.68) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| SCHEMBL8777107 | 0.88 | SRD5A1 (0.72) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| SCHEMBL8777104 | 0.88 | SRD5A1 (0.72) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| SCHEMBL8777125 | 0.88 | SRD5A1 (0.72) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611374-B1 | 17-BETA-SUBSTITUTED 4-AZA-5-ALPHA-ANDROSTAN-3-ONE DERIVATIVES | PHARMACIA & UPJOHN SPA (IT) | 1997-10-22 | — | — | EP | claimed |
| US-5418238-A | 17β-substituted 4-aza-5α-androstan-3-one derivatives | FARMITALIA CARLO ERBA S.R.L. (IT) | 1995-05-23 | — | — | US | claimed |
| EP-0611374-B1 | 17-BETA-SUBSTITUTED 4-AZA-5-ALPHA-ANDROSTAN-3-ONE DERIVATIVES | PHARMACIA & UPJOHN SPA (IT) | 1997-10-22 | — | — | EP | disclosed |
| US-5418238-A | 17β-substituted 4-aza-5α-androstan-3-one derivatives | FARMITALIA CARLO ERBA S.R.L. (IT) | 1995-05-23 | — | — | US | disclosed |