Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8777858 | 0.86 | F10 (0.49) | KMT2ASMN1; SMN2MEN1RAB9ANPC1 | |
| SCHEMBL8806034 | 0.80 | KMT2A (0.59) | KMT2ASMN1; SMN2MEN1HTTPKM | |
| SCHEMBL11806800 | 0.80 | MAOB (0.59) | KMT2ASMN1; SMN2MEN1MAOBRAB9A | |
| SCHEMBL8803427 | 0.79 | KMT2A (0.53) | KMT2ASMN1; SMN2MEN1HTTPKM | |
| SCHEMBL8803421 | 0.79 | KMT2A (0.53) | KMT2ASMN1; SMN2MEN1HTTPKM | |
| SCHEMBL8805456 | 0.79 | KMT2A (0.61) | KMT2ASMN1; SMN2MEN1HTTPKM | |
| SCHEMBL8804783 | 0.79 | KMT2A (0.61) | KMT2ASMN1; SMN2MEN1HTTPKM | |
| SCHEMBL8803651 | 0.79 | KMT2A (0.61) | KMT2ASMN1; SMN2MEN1HTTPKM | |
| SCHEMBL8803907 | 0.79 | KMT2A (0.61) | KMT2ASMN1; SMN2MEN1HTTPKM | |
| SCHEMBL3661171 | 0.77 | TOP1 (0.57) | KMT2AMEN1HTTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665216-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5576335-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0665216-A1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |