Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8777896 | 0.88 | USP2 (0.45) | ALDH1A1NPSR1USP2LMNATP53 | |
| SCHEMBL8777976 | 0.83 | TSHR (0.59) | TSHRALDH1A1LMNAKDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8777867 | 0.82 | TSHR (0.58) | TSHRALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL8777926 | 0.79 | KMT2A (0.63) | TSHRALDH1A1KDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL8778102 | 0.79 | TSHR (0.48) | TSHRALDH1A1NPSR1KDM4ESMN1; SMN2 | |
| SCHEMBL8778002 | 0.75 | F10 (0.47) | TSHRALDH1A1NPSR1LMNAKDM4E | |
| SCHEMBL8706854 | 0.74 | USP2 (0.46) | ALDH1A1NPSR1USP2LMNAKDM4E | |
| SCHEMBL8777858 | 0.73 | F10 (0.49) | ALDH1A1LMNASMN1; SMN2KMT2ACYP1A2 | |
| SCHEMBL8778045 | 0.73 | TSHR (0.49) | TSHRALDH1A1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL8777846 | 0.72 | GAA (0.58) | TSHRALDH1A1NPSR1USP2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665216-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5576335-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0665216-A1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |