Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL876615 | 0.94 | PDE4B (0.44) | PDE4BMEN1KMT2APDE4APDE4C | |
| SCHEMBL683403 | 0.94 | PDE4B (0.44) | PDE4BMEN1KMT2APDE4APDE4C | |
| SCHEMBL681904 | 0.91 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL682647 | 0.91 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL877921 | 0.91 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2085057 | 0.91 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL876832 | 0.88 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2084493 | 0.88 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL681903 | 0.88 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL682940 | 0.88 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643000-A2 | THERAPEUTIC PIPERAZINES | Dart Neuroscience (Cayman) Ltd (KY) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012040258-A2 | THERAPEUTIC PIPERAZINES | HELICON THERAPEUTICS, INC. (US) | 2012-03-29 | — | — | WO | disclosed |