SCHEMBL8778864

SCHEMBL8778864

ClC(Cl)(Cl)c1ccc(Br)nc1

nearest known ligand 0.35

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.35
CHRNB2 P17787 3/20 0.33
CHRNA4 P43681 3/20 0.33
FDFT1 P37268 1/20 0.32
CYP11B1 P15538 1/20 0.31
CYP19A1 P11511 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25100553 0.78 FDFT1 (0.36) CHRNB2CHRNA4FDFT1CYP11B1CYP19A1
SCHEMBL67213 0.76 KMT2A (0.47) TSHR
SCHEMBL13010773 0.76 TSHR (0.39) TSHRCHRNB2CHRNA4
SCHEMBL31500776 0.73 TSHR (0.41) TSHRCYP19A1
SCHEMBL5720313 0.73 TSHR (0.36) TSHRCYP19A1
SCHEMBL4985623 0.73 TSHR (0.41) TSHRCYP19A1
SCHEMBL24129962 0.73 PDE2A (0.38) CHRNB2CHRNA4CYP11B1CYP19A1
SCHEMBL30043054 0.73 TNKS (0.37) CHRNB2CHRNA4FDFT1
SCHEMBL23956200 0.73 FDFT1 (0.33) CHRNB2CHRNA4FDFT1
SCHEMBL746530 0.73 TNKS (0.37) CHRNB2CHRNA4FDFT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0700903-B1 PROCESS FOR PRODUCING CYANOPYRIDINE IHARA CHEMICAL IND CO (JP) 1997-11-12 EP disclosed
US-5675012-A REACTING AMMONIUM HALIDE WITH TRICHLOROMETHYLPYRIDINE IN PRESENCE OF A COPPER AND ZINC COMPOUND IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 1997-10-07 US disclosed
EP-0700903-A1 PROCESS FOR PRODUCING CYANOPYRIDINE IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 1996-03-13 EP disclosed
US-4184041-A 2-Substituted-5-trifluoromethylpyridine compounds ISHIHARA SANGYO KAISHA LTD. (JP) 1980-01-15 US disclosed