Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 11/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL785044 | 0.84 | CRBN (0.42) | CRBNMAPTHTR2AHTR2CHTR2B | |
| SCHEMBL484302 | 0.84 | CRBN (0.42) | CRBNMAPTHTR2AHTR2CHTR2B | |
| SCHEMBL484526 | 0.81 | MAPT (0.40) | MTNR1BMTNR1ACRBNMAPT | |
| SCHEMBL785796 | 0.81 | MAPT (0.40) | MTNR1BMTNR1ACRBNMAPT | |
| SCHEMBL785795 | 0.79 | CRBN (0.42) | CRBNMAPTHTR2AHTR2CHTR2B | |
| SCHEMBL2816152 | 0.79 | CRBN (0.42) | CRBNMAPTHTR2AHTR2CHTR2B | |
| SCHEMBL785723 | 0.79 | CRBN (0.42) | CRBNMAPTHTR2AHTR2CHTR2B | |
| SCHEMBL785475 | 0.78 | MAPT (0.41) | MTNR1BCRBNMAPTHTR2AHTR2C | |
| SCHEMBL785549 | 0.78 | MAPT (0.41) | CRBNMAPTHTR2AHTR2CHTR2B | |
| SCHEMBL484776 | 0.78 | MAPT (0.41) | MTNR1BCRBNMAPTHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619178-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012038081-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-03-29 | — | — | WO | disclosed |