Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | AR | P10275 | 11/20 | 0.57 |
| ▸ | PARP1 | P09874 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28857250 | 0.95 | PRMT5 (0.58) | PRMT5POLBSMN1; SMN2ALDH1A1AR | |
| SCHEMBL30107056 | 0.94 | PARP1 (0.59) | PRMT5POLBSMN1; SMN2ALDH1A1AR | |
| SCHEMBL19902481 | 0.94 | PARP1 (0.59) | PRMT5POLBSMN1; SMN2ALDH1A1AR | |
| SCHEMBL29983745 | 0.94 | PARP1 (0.59) | PRMT5POLBSMN1; SMN2ALDH1A1AR | |
| Fluoride SCHEMBL28857369 | 0.92 | PARP1 (0.61) | PRMT5POLBSMN1; SMN2ALDH1A1AR | |
| SCHEMBL21575767 | 0.90 | PRMT5 (0.64) | PRMT5POLBSMN1; SMN2ALDH1A1AR | |
| SCHEMBL30231202 | 0.82 | PRMT5 (0.68) | PRMT5POLBSMN1; SMN2ALDH1A1AR | |
| SCHEMBL7462930 | 0.82 | PRMT5 (0.68) | PRMT5POLBSMN1; SMN2ALDH1A1AR | |
| SCHEMBL6366635 | 0.82 | PRMT5 (0.58) | PRMT5POLBSMN1; SMN2ARPARP1 | |
| SCHEMBL20229818 | 0.81 | SMN1; SMN2 (0.49) | PRMT5POLBSMN1; SMN2ALDH1A1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0498722-B1 | Bicyclic nitrogen compounds, their preparation, intermediates obtained, their use as pharmaceuticals and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1997-07-30 | — | — | EP | claimed |
| JP-5065215-A | — | — | None | — | — | JP | disclosed |
| EP-0498722-B1 | Bicyclic nitrogen compounds, their preparation, intermediates obtained, their use as pharmaceuticals and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1997-07-30 | — | — | EP | disclosed |
| JP-H0565215-A | HAIR GROWTH AGENT | KAO CORP | 1993-03-19 | — | — | JP | disclosed |