Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.59 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.59 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.59 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8780923 | 0.97 | KCNH2 (0.56) | KCNH2SLC6A4SLC22A2ADRB1SLC47A2 | |
| SCHEMBL8780820 | 0.97 | KCNH2 (0.58) | KCNH2SLC6A4SLC22A2ADRB1SLC47A2 | |
| Dimethylamine SCHEMBL8780972 | 0.94 | KCNH2 (0.55) | KCNH2SLC6A4SLC22A2ADRB1SLC47A2 | |
| SCHEMBL8780861 | 0.92 | KCNH2 (0.61) | KCNH2SLC6A4SLC22A2ADRB1SLC47A2 | |
| SCHEMBL8780762 | 0.91 | KCNH2 (0.57) | KCNH2SLC6A4SLC22A2ADRB1SLC47A2 | |
| SCHEMBL8781005 | 0.89 | KCNH2 (0.57) | KCNH2SLC6A4SLC22A2ADRB1SLC47A2 | |
| SCHEMBL8780915 | 0.89 | KCNH2 (0.57) | KCNH2SLC6A4SLC22A2ADRB1SLC47A2 | |
| SCHEMBL8780851 | 0.88 | KCNH2 (0.55) | KCNH2SLC6A4SLC22A2ADRB1SLC47A2 | |
| SCHEMBL8780862 | 0.87 | KCNH2 (0.59) | KCNH2SLC6A4SLC22A2ADRB1SLC47A2 | |
| SCHEMBL8780806 | 0.86 | KCNH2 (0.56) | KCNH2SLC6A4SLC22A2ADRB1SLC47A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0697407-B1 | Pyrimidinedione derivatives and antiarrhythmic compositions containing same | MITSUI TOATSU CHEMICALS (JP) | 1997-06-25 | — | — | EP | disclosed |
| EP-0697407-A1 | Pyrimidinedione derivatives and antiarrhythmic compositions containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-02-21 | — | — | EP | disclosed |