Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 20/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874827 | 0.84 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL883529 | 0.79 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL883649 | 0.74 | LRRK2 (0.79) | LRRK2 | |
| SCHEMBL10225334 | 0.73 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL883532 | 0.73 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL875298 | 0.73 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL10224684 | 0.73 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL883509 | 0.73 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL875349 | 0.72 | LRRK2 (0.74) | LRRK2 | |
| SCHEMBL10224627 | 0.71 | LRRK2 (1.00) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619201-A1 | PYRAZOLOPYRIDINES AS INHIBITORS OF THE KINASE LRRK2 | Medical Research Council Technology (GB) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012038743-A1 | PYRAZOLOPYRIDINES AS INHIBITORS OF THE KINASE LRRK2 | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2012-03-29 | — | — | WO | disclosed |