Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.57 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.57 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.57 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.57 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.57 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.57 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8784579 | 0.81 | GRIN1 (0.70) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| SCHEMBL8784031 | 0.79 | GRIN1 (0.62) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| SCHEMBL8784690 | 0.76 | KDM4E (0.59) | KDM4ECYP1A2POLBCYP3A4CYP2C9 | |
| SCHEMBL1612505 | 0.75 | KDM4E (0.79) | KDM4EMAPTCYP1A2POLBCYP3A4 | |
| SCHEMBL8783774 | 0.71 | FASN (0.74) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| SCHEMBL8783859 | 0.69 | GRIN1 (0.70) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| SCHEMBL8057203 | 0.69 | GRIN1 (0.49) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| SCHEMBL8784109 | 0.68 | CYP1A2 (0.71) | KDM4ECYP1A2POLBCYP3A4CYP2C9 | |
| SCHEMBL8784105 | 0.68 | CYP1A2 (0.71) | KDM4ECYP1A2POLBCYP3A4CYP2C9 | |
| SCHEMBL15193380 | 0.68 | MAPT (0.60) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0481676-B1 | Hydroxyquinolone derivatives | MERCK SHARP & DOHME (GB) | 1997-01-29 | — | — | EP | claimed |
| US-5348962-A | Nervous system disorders; schizophrenia | MERCK SHARPE & DOHME LTD. | 1994-09-20 | — | — | US | claimed |
| EP-0481676-A1 | Hydroxyquinolone derivatives | MERCK SHARP & DOHME LTD. (GB) | 1992-04-22 | — | — | EP | claimed |
| EP-0481676-B1 | Hydroxyquinolone derivatives | MERCK SHARP & DOHME (GB) | 1997-01-29 | — | — | EP | disclosed |
| US-5559125-A | NMDA AND AMPA RECEPTOR ANTAGONISTS, SCHIZOPHRENIA | MERCK, SHARP & DOHME LIMITED (GB) | 1996-09-24 | — | — | US | disclosed |
| US-5348962-A | Nervous system disorders; schizophrenia | MERCK SHARPE & DOHME LTD. | 1994-09-20 | — | — | US | disclosed |
| EP-0481676-A1 | Hydroxyquinolone derivatives | MERCK SHARP & DOHME LTD. (GB) | 1992-04-22 | — | — | EP | disclosed |