SCHEMBL8786183

SCHEMBL8786183

COc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1

nearest known ligand 0.78

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 20/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8784888 0.91 TACR1 (0.65) TACR1
SCHEMBL8784841 0.87 TACR1 (1.00) TACR1
SCHEMBL5331418 0.86 TACR1 (0.80) TACR1
SCHEMBL8786442 0.85 TACR1 (0.77) TACR1
SCHEMBL8786688 0.85 TACR1 (0.77) TACR1
SCHEMBL5315947 0.84 TACR1 (0.76) TACR1
SCHEMBL8785500 0.83 TACR1 (0.65) TACR1
SCHEMBL8786855 0.79 TACR1 (1.00) TACR1
SCHEMBL8787140 0.78 TACR1 (0.72) TACR1
SCHEMBL8784772 0.77 TACR1 (0.65) TACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0585913-B1 Condensed heterocyclic compounds, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1997-12-29 EP disclosed
US-5482967-A LOWERING CHOLESTEROL TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-01-09 US disclosed
EP-0585913-A2 Condensed heterocyclic compounds, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1994-03-09 EP disclosed