Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 20/20 | 1.00 |
| ▸ | DRD2 | P14416 | 18/20 | 1.00 |
| ▸ | DRD3 | P35462 | 15/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8786458 | 0.93 | DRD4 (1.00) | DRD4DRD2DRD3 | |
| SCHEMBL8786476 | 0.92 | DRD4 (1.00) | DRD4DRD2DRD3 | |
| SCHEMBL8786338 | 0.90 | DRD4 (0.83) | DRD4DRD2DRD3 | |
| SCHEMBL8786329 | 0.89 | DRD4 (0.81) | DRD4DRD2DRD3 | |
| SCHEMBL8786357 | 0.88 | DRD4 (1.00) | DRD4DRD2DRD3 | |
| SCHEMBL8786774 | 0.88 | DRD4 (1.00) | DRD4DRD2DRD3 | |
| SCHEMBL8785940 | 0.87 | DRD4 (0.80) | DRD4DRD2DRD3 | |
| SCHEMBL8786161 | 0.87 | DRD4 (0.77) | DRD4DRD2DRD3 | |
| SCHEMBL2334776 | 0.87 | DRD4 (1.00) | DRD4DRD2DRD3 | |
| SCHEMBL8786607 | 0.83 | DRD4 (0.86) | DRD4DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0719264-B1 | IMIDAZOLONE AND OXAZOLONE DERIVATIVES AS DOPAMINE ANTAGONISTS | MERCK SHARP & DOHME (GB) | 1997-12-29 | — | — | EP | claimed |
| EP-0719264-A1 | IMIDAZOLONE AND OXAZOLONE DERIVATIVES AS DOPAMINE ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 1996-07-03 | — | — | EP | claimed |
| WO-1995007904-A1 | IMIDAZOLONE AND OXAZOLONE DERIVATIVES AS DOPAMINE ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1995-03-23 | — | — | WO | claimed |
| EP-0719264-B1 | IMIDAZOLONE AND OXAZOLONE DERIVATIVES AS DOPAMINE ANTAGONISTS | MERCK SHARP & DOHME (GB) | 1997-12-29 | — | — | EP | disclosed |
| US-5698573-A | Imidazolone and oxazolone derivatives as dopamine antagonists | MERCK, SHARP & DOHME, LTD. (GB) | 1997-12-16 | — | — | US | disclosed |
| EP-0719264-A1 | IMIDAZOLONE AND OXAZOLONE DERIVATIVES AS DOPAMINE ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 1996-07-03 | — | — | EP | disclosed |
| WO-1995007904-A1 | IMIDAZOLONE AND OXAZOLONE DERIVATIVES AS DOPAMINE ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1995-03-23 | — | — | WO | disclosed |