Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.58 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.58 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 4/20 | 0.45 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL857919 | 0.88 | FGFR1 (0.58) | FGFR1FGFR4BRD4NTRK1KIT | |
| SCHEMBL857698 | 0.84 | FGFR1 (0.60) | FGFR1FGFR4BRD4NTRK1KIT | |
| SCHEMBL858280 | 0.82 | FGFR1 (0.66) | FGFR1FGFR4BRD4NTRK1KIT | |
| SCHEMBL857207 | 0.80 | FGFR1 (0.60) | FGFR1FGFR4BRD4NTRK1KIT | |
| SCHEMBL857961 | 0.80 | FGFR1 (0.62) | FGFR1FGFR4BRD4NTRK1KIT | |
| SCHEMBL878730 | 0.78 | FGFR1 (0.69) | FGFR1FGFR4BRD4NTRK1KIT | |
| SCHEMBL13911278 | 0.78 | FGFR1 (0.57) | FGFR1FGFR4BRD4NTRK1KIT | |
| SCHEMBL858570 | 0.76 | FGFR1 (0.57) | FGFR1FGFR4BRD4NTRK1KIT | |
| SCHEMBL878736 | 0.76 | FGFR1 (0.57) | FGFR1FGFR4BRD4NTRK1KIT | |
| SCHEMBL857805 | 0.74 | FGFR1 (1.00) | FGFR1FGFR4CYP2C9CYP3A4CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143271-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2012-03-27 | — | — | US | disclosed |