Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 8/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 10/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.57 |
| ▸ | BRAF | P15056 | 2/20 | 0.53 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | PIR | O00625 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.53 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | STK16 | O75716 | 1/20 | 0.53 |
| ▸ | OXSR1 | O95747 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | FES | P07332 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL878723 | 0.91 | CYP3A4 (0.71) | CYP3A4CYP2C9CYP2C19BRAFBMPR1B | |
| SCHEMBL299103 | 0.91 | CYP3A4 (0.70) | CYP3A4CYP2C9CYP2C19BRAFBMPR1B | |
| SCHEMBL12725146 | 0.89 | CYP3A4 (0.69) | CYP3A4CYP2C9CYP2C19BRAFBMPR1B | |
| SCHEMBL297958 | 0.88 | CYP3A4 (0.79) | CYP3A4CYP2C9CYP2C19BRAFBMPR1B | |
| SCHEMBL12725071 | 0.86 | CYP2C9 (0.63) | CYP3A4CYP2C9CYP2C19BRAFBMPR1B | |
| SCHEMBL12964477 | 0.86 | CYP2C19 (0.67) | CYP3A4CYP2C9CYP2C19BRAFBMPR1B | |
| SCHEMBL298244 | 0.86 | CYP3A4 (0.84) | CYP3A4CYP2C9CYP2C19BRAFBMPR1B | |
| SCHEMBL12725003 | 0.86 | CYP3A4 (0.60) | CYP3A4CYP2C9CYP2C19BRAFBMPR1B | |
| SCHEMBL297208 | 0.85 | CYP3A4 (0.74) | CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL878798 | 0.85 | CYP3A4 (0.60) | CYP3A4CYP2C9CYP2C19BRAFBMPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143271-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2012-03-27 | — | — | US | disclosed |
| US-20110059963-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON, INC. | 2011-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110059963-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | MAP3K20, MAP3K13, MAP3K8 | CYP3A4 4658/4885CYP2C9 4746/4885CYP2C19 4579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.