Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8790880 | 0.96 | ABCG2 (0.52) | ABCG2LMNAL3MBTL1KMT2AMEN1 | |
| SCHEMBL8789751 | 0.90 | ABCG2 (0.69) | ABCG2LMNAL3MBTL1KMT2AMEN1 | |
| SCHEMBL8835762 | 0.89 | ABCG2 (0.56) | ABCG2LMNAL3MBTL1KMT2AMEN1 | |
| SCHEMBL8789767 | 0.89 | ABCG2 (0.50) | ABCG2LMNAL3MBTL1KMT2AMEN1 | |
| SCHEMBL8789900 | 0.88 | ABCG2 (0.68) | ABCG2LMNAL3MBTL1KMT2AMEN1 | |
| SCHEMBL8789775 | 0.87 | ABCG2 (0.42) | ABCG2LMNAKMT2AMEN1MAPT | |
| SCHEMBL8789470 | 0.86 | ABCG2 (0.47) | ABCG2LMNAL3MBTL1KMT2AMEN1 | |
| SCHEMBL8790230 | 0.84 | ABCG2 (0.66) | ABCG2LMNAL3MBTL1KMT2AMEN1 | |
| SCHEMBL8788669 | 0.83 | ABCG2 (0.57) | ABCG2KMT2AMEN1MAPTKDM4E | |
| SCHEMBL8789555 | 0.82 | ABCG2 (0.77) | ABCG2LMNAL3MBTL1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569380-B1 | ACRIDINE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-28 | — | — | EP | disclosed |
| US-5604237-A | IMPROVE OR INCREASE EFFICACY OF ANTITUMOR AGENT, INCREASE OR RESTORE SENSITIVITY OF TUMOR TO ANTITUMOR AGENT, REVERSE OR REDUCE RESISTANCE OF TUMOR TO ANTITUMOR AGENT | LABORATOIRES GLAXO SA (FR) | 1997-02-18 | — | — | US | disclosed |
| EP-0494623-A1 | Acridine derivatives | LABORATOIRES GLAXO SA (FR) | 1992-07-15 | — | — | EP | disclosed |