Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 8/20 | 0.80 |
| ▸ | HTR1D | P28221 | 5/20 | 0.80 |
| ▸ | GABRP | O00591 | 1/20 | 0.69 |
| ▸ | GABRD | O14764 | 1/20 | 0.69 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.69 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.69 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.69 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.69 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.69 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.69 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.69 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.69 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.69 |
| ▸ | GABRE | P78334 | 1/20 | 0.69 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.69 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.69 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.69 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.69 |
| ▸ | HTR1A | P08908 | 3/20 | 0.68 |
| ▸ | HTR6 | P50406 | 7/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8790009 | 1.00 | HTR1B (0.80) | HTR1BHTR1DGABRPGABRDGABRA1 | |
| SCHEMBL8507160 | 0.89 | HTR1B (1.00) | HTR1BHTR1DGABRPGABRDGABRA1 | |
| SCHEMBL8507164 | 0.89 | HTR1B (1.00) | HTR1BHTR1DGABRPGABRDGABRA1 | |
| SCHEMBL18408992 | 0.87 | HTR1B (0.83) | HTR1BHTR1DGABRPGABRDGABRA1 | |
| SCHEMBL14593918 | 0.87 | HTR1B (0.83) | HTR1BHTR1DGABRPGABRDGABRA1 | |
| SCHEMBL8984140 | 0.87 | HTR1B (0.74) | HTR1BHTR1DGABRPGABRDGABRA1 | |
| SCHEMBL7097372 | 0.86 | HTR1B (0.77) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL7097373 | 0.86 | HTR1B (0.77) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL8790809 | 0.85 | HTR1B (0.72) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL8790804 | 0.85 | HTR1B (0.72) | HTR1BHTR1DHTR1AHTR6CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0592438-B1 | INDOLE DERIVATIVES | PFIZER (US) | 1997-08-27 | — | — | EP | disclosed |
| US-5607951-A | SEROTONIN AGONIST FOR NERVOUS SYSTEM DISORDERS, ANALGESICS AND PSYCHOTHERAPEUTICS | PFIZER INC (US) | 1997-03-04 | — | — | US | disclosed |
| US-5578612-A | Indole derivatives | PFIZER INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5559129-A | SEROTONIN (5HT1) ANTAGONIST FOR TREATMENT OF DEPRESSION, ANXIETY, EATING DISORDERS, OBESITY, DRUG ABUSE, HEADACHES, AND PAIN | PFIZER INC (US) | 1996-09-24 | — | — | US | disclosed |
| US-5559246-A | PROCESS OF DEHYDROHALOGENATION FOR CYCLIZATION TO PRODUCE PSYCHOTHERAPEUTIC AGENTS AND ANTISEROTONIN ANTAGONIST | PFIZER INC. (US) | 1996-09-24 | — | — | US | disclosed |
| US-5545644-A | SEROTONIN AGONISTS; HYPOTENSIVE AND ANXIOLYTIC AGENTS; ANALGESICS; ANTIDEPRESSANTS; EATING DISORDERS; DRUG ABUSE; HEADACHES; VASCULAR DISORDERS | PFIZER INC. (US) | 1996-08-13 | — | — | US | disclosed |
| EP-0592438-A1 | INDOLE DERIVATIVES. | PFIZER (US) | 1994-04-20 | — | — | EP | disclosed |
| WO-1992006973-A1 | INDOLE DERIVATIVES | PFIZER INC. (US) | 1992-04-30 | — | — | WO | disclosed |