Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8789648 | 0.93 | ABCG2 (0.63) | ABCG2ABCB1MAPTTP53BCHE | |
| SCHEMBL8789264 | 0.90 | ABCG2 (0.55) | ABCG2ABCB1MAPTTP53BCHE | |
| SCHEMBL8789595 | 0.89 | ABCG2 (0.54) | ABCG2ABCB1MAPTBCHEACHE | |
| SCHEMBL8790168 | 0.89 | ABCG2 (0.62) | ABCG2ABCB1MAPTTP53BCHE | |
| SCHEMBL8789736 | 0.88 | ABCG2 (0.55) | ABCG2ABCB1MAPTTP53BCHE | |
| SCHEMBL8789541 | 0.88 | ABCG2 (0.65) | ABCG2ABCB1MAPTBCHEACHE | |
| SCHEMBL8789486 | 0.88 | ABCG2 (0.61) | ABCG2ABCB1MAPTTP53BCHE | |
| SCHEMBL8789457 | 0.88 | ABCG2 (0.60) | ABCG2ABCB1MAPTTP53BCHE | |
| SCHEMBL8789662 | 0.88 | ABCG2 (0.64) | ABCG2ABCB1MAPTTP53ALDH1A1 | |
| SCHEMBL8789696 | 0.88 | ABCG2 (0.53) | ABCG2ABCB1MAPTBCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569380-B1 | ACRIDINE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-28 | — | — | EP | disclosed |
| US-5604237-A | IMPROVE OR INCREASE EFFICACY OF ANTITUMOR AGENT, INCREASE OR RESTORE SENSITIVITY OF TUMOR TO ANTITUMOR AGENT, REVERSE OR REDUCE RESISTANCE OF TUMOR TO ANTITUMOR AGENT | LABORATOIRES GLAXO SA (FR) | 1997-02-18 | — | — | US | disclosed |
| EP-0494623-A1 | Acridine derivatives | LABORATOIRES GLAXO SA (FR) | 1992-07-15 | — | — | EP | disclosed |